The New Paradigm
The conclusions of the above studies are that alcohol leaves the lungs
by diffusing from the bronchial circulation through the airway tissue
where it is picked up by the inspired air. By the time it reaches the
alveoli, it has picked-up as much alcohol as is possible. Therefore, no
additional alcohol can be picked up in the alveoli. On exhalation, some
of the alcohol is redeposited on the airway surfaces. All of the alcohol
exhaled at the mouth comes from the airway surface via the bronchial
circulation. No alcohol originates from the pulmonary circulation in the
alveoli. The fact that alcohol comes primarily from the airways is why
the breath alcohol concentration can be so easily changed by changing
the breathing pattern. This contributes to the very large variation in
the alcohol breath test
readings obtained from actual subjects.
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The lungs have a relatively simple, but non-uniform, anatomical structure. The
airways are a branching, tree-like arrangement of tubes. Inspired air moves
through progressively shorter, narrower and more numerous airways. These airways
are lined with mucus at a temperature varying between approximately 34oC
at the mouth and 37oC in the very smallest airways. However, this
temperature range varies depending on the breathing pattern. The membranes
separating the air in the alveoli and the blood in the capillaries are so
thin that inert gases such as alcohol equilibrate between blood and air
very rapidly. With exhalation, air within the alveoli is conducted along
the airways to the mouth.
During inspiration, air is heated and humidified as it passes through
the upper airways. Some water within the mucous layer or watery sub-mucous
layer will vaporize and heat stored in the airways will be picked up by
the inspired gas and taken to the alveoli. During exhalation, the process
reverses; fully humidified air at core body temperature is cooled by the
cooler airway mucosa and water vapor condenses on the mucosa. This water
and heat exchange process is vital because it conditions the inspired air
to avoid damaging the delicate alveolar cells while conserving water and
heat from major loss in the exhaled air. Under normal environmental conditions,
exhaled gas has less heat and less water vapor than does alveolar air.
The dynamics of soluble gas exchange are similar to the dynamics of
heat and water exchange. These processes are analyzed using analogous
equations. The fact that respired air exchanges heat and water with the
airways implies similar soluble gas exchange processes. This interaction
of soluble gases with airway mucosa is well documented. The degree of
interaction is directly related to the solubility of the gas in the airway
mucosa and mucous lining. The very high solubility of alcohol in water
guarantees its strong interaction with airway tissue. Because this interaction
depends on temperature and airflow characteristics, variations in tidal volume
and frequency can have a substantial effect on the alcohol concentration in the
breath sample. This variation is affected by the difference in temperature between
the outside air and the alveolar air.
The exchanges of heat and of gas with the airways are complex and interactive
processes. The relative significance of this exchange depends on the effective
solubility of the gas in the mucosa. For the respiratory gases, oxygen and carbon
dioxide, airway tissue solubility is small. For both water and alcohol airway
solubility is quite large. Moreover, the exchange processes are interactive.
During inspiration, heat, water and alcohol are transported from the mucosa
to the air. The exchange of heat cools the mucosa causing an increase in its
alcohol solubility and, hence, a decrease in the partial pressure of alcohol
in the mucosa and a reduction in alcohol flux into the airway lumen. These
various processes have been integrated into a mathematical model developed by
Tsu et al and further refined by George et al which shows that during normal
breathing, the inspired air is equilibrated with alcohol, picking it up from
the airways, before reaching the seventeenth generation airways
(start of the
alveolar region). Upon reaching the alveoli a small amount of additional alcohol
is picked up because the solubility of alcohol in blood is lower than the
solubility of alcohol in water. The equilibrium partial pressure of alcohol
in vapor above blood is greater than in vapor above water at the same
temperature. With exhalation, the excess alcohol picked up in the alveoli is
rapidly lost to the airways within the sixteenth or fifteenth generation. Along
the airway, more alcohol is lost to the airways. The alcohol that arrives at the
mouth comes essentially from the airways and not from the alveoli. This is also
the case for water vapor. The humidification of inspired air is performed by the
airways.
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Figure 4. Airway alcohol exchange. |
The flux of alcohol from the mucus surface into the air
(positive values) during inspiration and the flux of
alcohol from the air to the mucus surface (negative
values) during expiration is demonstrated in Figure
4. This figure was calculated using a mathematical
model of the human airway structure. During inspiration, alcohol is taken up into the inspired air immediately at the mouth. The greatest alcohol uptake occurs in the trachea and generations 6 through 13. During expiration, the redeposition of alcohol occurs primarily at these same airway generations. The important conclusion from this work is that all of the alcohol that comes out of the mouth in the breath comes from the airway surfaces rather than from the alveolar regions.
The early basic assumption of the alcohol breath test was that the breath alcohol concentration was the same irrespective of the exhaled volume as long as the dead space volume is exhaled
(as shown in Figure 3). However, others have shown that the breath alcohol concentration depends on exhaled volume. The breath testing instrument takes a sample of air from the end of the breath whenever the subject stops but the volume of breath exhaled is neither controlled nor measured. Therefore, the apparent breath alcohol concentration depends on the volume of air delivered to the breath testing instrument. The last part of the breath can be well above the average single breath alcohol level because the alveolar plateau has a positive slope that is dependent on air temperature.
A sloping alveolar plateau for various low solubility gases has been explained by several factors including stratified inhomogeneity
(gas phase diffusion limitation), convection-diffusion interaction, sequential exhalation from regions with differing VA /Q and continuing gas exchange. None of these factors contribute substantially to the slope of the exhaled alcohol profile. Continuing gas exchange will contribute to the slope of the exhaled profile for respiratory gases
(CO2 and O2), but not inert gases.
Further variation in BrAC will result from changing the breathing pattern immediately before delivering the sample breath. Hyperventilation for 20 seconds prior to delivering a sample breath to the breath tester causes an 11% reduction in BrAC. Three deep breaths prior to the sample breath reduces BrAC by 4%. After breath-holding for 15 seconds prior to exhalation, the BrAC increases by 12%
(for a minimum exhalation) and 6% (for a maximum exhalation). A 30 second breathhold prior to exhalation increases BrAC by 16%. These effects are caused by the respective cooling or warming of the airways and the data further support the airway surface interaction of alcohol as the mechanism causing the changing alcohol concentration during exhalation.
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Breath Alcohol Concentration
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Figure 6. Exhaled Breath Alcohol Profile. |
In many states, it is illegal to drive a motor vehicle with a breath alcohol concentration of 0.08 gm/210 liters or more. Have you ever considered what is meant by
"breath"? What is the breath and to what part of the breath is the statue referring? Webster's New World Dictionary has several definitions of breath, but the most relevant is
"air taken into the lungs and then let out". Air becomes breath when it goes into the lungs AND is
exhaled from the lungs. The only air that fulfills that criteria is the air that is exhaled from the mouth or nose. Any air within the lungs is not breath. Only that which is exhaled can be considered as breath.
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Figure 7. Exhaled Breath Alcohol Profile with Valid Breath Samples Identified. |
The exhaled alcohol profile is shown in (Figure 6). At the beginning of exhalation, the breath has a zero or near zero BrAC. As exhalation progresses, the BrAC increases, initially quite rapidly, but eventually the rate of increase of BrAC slows down. It does not level off
until the subject stops exhalation. All of this is "breath". Since the specific portion of the breath that is sought to determine alcohol concentration is not defined, we can only surmise that the average of the breath is meant. The average of the breath would include some initial breath with lower EtOH and some of the later breath with a higher concentration. The average of the breath alcohol will be a value that is near the 5 second point of exhalation
(Figure 7). If a subject exhales for five seconds and then stops, the BrAC will be close to the average of the entire breath. Any exhalation beyond this approximate time will result in a value that will be higher than the average BrAC. Therefore the average BrAC is ALWAYS less than the breath test machine reading.
Beware of the over-eager prosecution expert who may say that the part of the breath that the state wants is the
"deep-lung air". This is incorrect and must be vigorously opposed. First of all the deep-lung air is not breath
(by Webster's definition). The technician will say this because he/she believes (correctly so) that any sample of breath is usually lower than a deep-lung
(alveolar) sample. When we had a blood standard
(illegal to drive with a BAC of 0.10 mg/dl or more, as measured by the breath), this would be a reasonable argument. However, we now have a breath standard and, therefore, the deep-lung air is not relevant.
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1800 DUI Laws
The Alcohol Breath Test 
